ABSTRACT
Talinum Triangulare (Family: Portulacaceae) is an herbaceous perennial plant widely grown in tropical regions as a leaf vegetable with a blood-glucose-lowering effect, but its mechanism of action are still unknown. Here we report a hypoglycemic activity of Methanolic Extract of Talinum Triangulare Leaf (METTL) in healthy, glucose loaded and Streptozotocin (STZ)-induced diabetic rats. Animals either healthy or STZ-induced diabetic show significantly lowered blood glucose levels after 2 weeks of METTL treatment (250 mg/kg), it significantly reduced blood glucose levels compared with that in diabetic control rats. Additionally, the increase in blood glucose levels after administration of glucose (1.2 g/kg) in normal rats is significantly decreased and the oral glucose tolerance (OGTT) of STZ-induced diabetic rats is largely improved by METTL treatment. However, co-administration of METTL with glipizide, an oral hypoglycemic drug, it produces synergistic effect. We conclude that METTL has a significant anti hyperglycemic effect. Continuous glucose monitoring is needed in diabetic patients.